32 destinations have scheduled flights from LUX, about 238 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Francisco de Sá Carneiro Airport (OPO) | 19 | Ryanair Ltd., Easyjet Airline Company Limited, TAP Portugal, Luxair | — |
| London City Airport (LCY) | 17 | Luxair | — |
| Copenhagen Kastrup Airport (CPH) | 14 | Luxair, SAS | — |
| Frankfurt Main Airport (FRA) | 12 | AIR DOLOMITI S.p.A. LINEE AEREE REGIONALI EUROPEE | — |
| Munich Airport (MUC) | 12 | Lufthansa Cargo, Luxair | — |
| Nice-Côte d'Azur Airport (NCE) | 12 | Luxair, Volotea | — |
| Amsterdam Airport Schiphol (AMS) | 11 | KLM | — |
| Palma de Mallorca Airport (PMI) | 11 | Luxair, Ryanair Ltd. | — |
| Josep Tarradellas Barcelona-El Prat Airport (BCN) | 10 | Ryanair Ltd., Luxair | — |
| Vienna International Airport (VIE) | 10 | Luxair | — |
| Zürich Airport (ZRH) | 10 | SWISS | — |
| Adolfo Suárez Madrid–Barajas Airport (MAD) | 9 | Luxair, Ryanair Ltd. | — |
| İstanbul Airport (IST) | 7 | THY - Turkish Airlines | — |
| Lisbon Humberto Delgado Airport (LIS) | 7 | TAP Portugal | — |
| Berlin Brandenburg Airport (BER) | 6 | Luxair | — |
| Milan Malpensa International Airport (MXP) | 6 | Luxair | — |
| London Stansted Airport (STN) | 6 | Ryanair Ltd. | — |
| Rome–Fiumicino Leonardo da Vinci International Airport (FCO) | 5 | Luxair | — |
| Geneva International Airport (GVA) | 5 | Luxair | — |
| Milano Linate Airport (LIN) | 5 | Luxair | — |
| Warsaw Chopin Airport (WAW) | 5 | LOT Polish Airlines | — |
| Málaga-Costa del Sol Airport (AGP) | 4 | Luxair | — |
| Dublin Airport (DUB) | 4 | Luxair | — |
| Faro - Gago Coutinho International Airport (FAO) | 4 | Luxair | — |
| Hamburg Helmut Schmidt Airport (HAM) | 4 | Luxair | — |
| London Heathrow Airport (LHR) | 4 | British Airways | — |
| Marseille Provence Airport (MRS) | 4 | Ryanair Ltd. | — |
| Il Caravaggio International Airport (BGY) | 3 | Ryanair Ltd. | — |
| Florence Airport, Peretola (FLR) | 3 | Luxair | — |
| Heraklion International Nikos Kazantzakis Airport (HER) | 3 | Luxair | — |
| Gran Canaria Airport (LPA) | 3 | Luxair | — |
| Venice Marco Polo Airport (VCE) | 3 | Luxair | — |
GET /routes returns each scheduled flight from LUX: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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