17 destinations have scheduled flights from GSO, about 246 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Charlotte Douglas International Airport (CLT) | 56 | American Airlines | — |
| LaGuardia Airport (LGA) | 50 | Delta Air Lines, American Airlines | — |
| Hartsfield Jackson Atlanta International Airport (ATL) | 35 | Delta Air Lines | — |
| Chicago O'Hare International Airport (ORD) | 20 | Envoy Air Inc., Delta Air Lines | — |
| Detroit Metropolitan Wayne County Airport (DTW) | 14 | Delta Air Lines | — |
| Washington Dulles International Airport (IAD) | 14 | Albatross Airlines | — |
| Philadelphia International Airport (PHL) | 14 | American Airlines | — |
| Dallas Fort Worth International Airport (DFW) | 7 | American Airlines | — |
| Ronald Reagan Washington National Airport (DCA) | 6 | American Airlines | — |
| Newark Liberty International Airport (EWR) | 6 | Albatross Airlines | — |
| Miami International Airport (MIA) | 6 | Envoy Air Inc. | — |
| Frederick W. Smith International Airport (MEM) | 5 | Four Island Air | — |
| Louisville Muhammad Ali International Airport (SDF) | 4 | UPS Airlines | — |
| Greenville-Spartanburg International Airport (GSP) | 3 | UPS Airlines | — |
| Bradley International Airport (BDL) | 2 | Mexicana | — |
| Indianapolis International Airport (IND) | 2 | Four Island Air | — |
| Orlando International Airport (MCO) | 2 | Mexicana | — |
GET /routes returns each scheduled flight from GSO: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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