53 destinations have scheduled flights from HOU, about 1,107 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Dallas Love Field (DAL) | 84 | Southwest Airlines Co., Expressjet | — |
| Louis Armstrong New Orleans International Airport (MSY) | 51 | Southwest Airlines Co. | — |
| Denver International Airport (DEN) | 49 | Southwest Airlines Co. | — |
| Hartsfield Jackson Atlanta International Airport (ATL) | 48 | Southwest Airlines Co., Delta Air Lines | — |
| Phoenix Sky Harbor International Airport (PHX) | 46 | Southwest Airlines Co. | — |
| Dallas Fort Worth International Airport (DFW) | 38 | American Airlines, Envoy Air Inc. | — |
| Orlando International Airport (MCO) | 36 | Southwest Airlines Co. | — |
| Chicago Midway International Airport (MDW) | 36 | Southwest Airlines Co. | — |
| Nashville International Airport (BNA) | 35 | Southwest Airlines Co. | — |
| Midland International Air and Space Port (MAF) | 33 | Southwest Airlines Co. | — |
| St. Louis Lambert International Airport (STL) | 32 | Southwest Airlines Co. | — |
| Harry Reid International Airport (LAS) | 31 | Southwest Airlines Co., Kyrgyz International Airlines | — |
| Baltimore/Washington International Thurgood Marshall Airport (BWI) | 27 | Southwest Airlines Co. | — |
| El Paso International Airport (ELP) | 26 | Southwest Airlines Co. | — |
| OKC Will Rogers World Airport (OKC) | 26 | Southwest Airlines Co. | — |
| Tampa International Airport (TPA) | 26 | Southwest Airlines Co. | — |
| Austin Bergstrom International Airport (AUS) | 25 | Southwest Airlines Co. | — |
| Ronald Reagan Washington National Airport (DCA) | 23 | Southwest Airlines Co. | — |
| Kansas City International Airport (MCI) | 23 | Southwest Airlines Co. | — |
| San Diego International Airport (SAN) | 23 | Southwest Airlines Co. | — |
| Albuquerque International Sunport (ABQ) | 22 | Southwest Airlines Co. | — |
| Valley International Airport (HRL) | 22 | Southwest Airlines Co. | — |
| Frederick W. Smith International Airport (MEM) | 22 | Southwest Airlines Co. | — |
| LaGuardia Airport (LGA) | 21 | Southwest Airlines Co. | — |
| San Antonio International Airport (SAT) | 21 | Southwest Airlines Co. | — |
| Los Angeles International Airport (LAX) | 17 | Southwest Airlines Co. | — |
| Fort Lauderdale Hollywood International Airport (FLL) | 16 | Southwest Airlines Co. | — |
| City of Colorado Springs Municipal Airport (COS) | 14 | Southwest Airlines Co. | — |
| Corpus Christi International Airport (CRP) | 14 | Southwest Airlines Co. | — |
| Indianapolis International Airport (IND) | 13 | Southwest Airlines Co. | — |
| Jackson-Medgar Wiley Evers International Airport (JAN) | 13 | Southwest Airlines Co. | — |
| Jacksonville International Airport (JAX) | 13 | Southwest Airlines Co. | — |
| Miami International Airport (MIA) | 13 | Southwest Airlines Co. | — |
| Birmingham-Shuttlesworth International Airport (BHM) | 12 | Southwest Airlines Co. | — |
| Cancún International Airport (CUN) | 12 | Southwest Airlines Co. | — |
| Northwest Florida Beaches International Airport (ECP) | 12 | Southwest Airlines Co. | — |
| Lubbock Preston Smith International Airport (LBB) | 12 | Southwest Airlines Co. | — |
| Pensacola International Airport (PNS) | 12 | Southwest Airlines Co. | — |
| Louisville Muhammad Ali International Airport (SDF) | 12 | Southwest Airlines Co. | — |
| Tulsa International Airport (TUL) | 12 | Southwest Airlines Co. | — |
| Destin-Fort Walton Beach Airport (VPS) | 12 | Southwest Airlines Co. | — |
| Sacramento International Airport (SMF) | 10 | Southwest Airlines Co. | — |
| Charleston International Airport (CHS) | 9 | Southwest Airlines Co. | — |
| Ontario International Airport (ONT) | 9 | Southwest Airlines Co. | — |
| Raleigh-Durham International Airport (RDU) | 8 | Southwest Airlines Co. | — |
| Juan Santamaría International Airport (SJO) | 7 | Southwest Airlines Co. | — |
| John Glenn Columbus International Airport (CMH) | 6 | Southwest Airlines Co. | — |
| Puerto Vallarta International Airport (PVR) | 6 | Southwest Airlines Co. | — |
| Long Beach International Airport (LGB) | 5 | Southwest Airlines Co. | — |
| Los Cabos International Airport (SJD) | 4 | Southwest Airlines Co. | — |
| Philip S. W. Goldson International Airport (BZE) | 3 | Southwest Airlines Co. | — |
| Daniel Oduber Quirós International Airport (LIR) | 3 | Southwest Airlines Co. | — |
| Tweed New Haven Airport (HVN) | 2 | Xtra Airways | — |
GET /routes returns each scheduled flight from HOU: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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