13 destinations have scheduled flights from MHT, about 161 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Baltimore/Washington International Thurgood Marshall Airport (BWI) | 35 | Southwest Airlines Co. | — |
| Ronald Reagan Washington National Airport (DCA) | 25 | American Airlines | — |
| Philadelphia International Airport (PHL) | 21 | American Airlines, UPS Airlines | — |
| Charlotte Douglas International Airport (CLT) | 18 | American Airlines | — |
| Orlando International Airport (MCO) | 14 | Southwest Airlines Co., Mexicana | — |
| Washington Dulles International Airport (IAD) | 13 | Albatross Airlines | — |
| Chicago O'Hare International Airport (ORD) | 12 | Envoy Air Inc. | — |
| Nantucket Memorial Airport (ACK) | 5 | Ameriflight, LLC | — |
| Louisville Muhammad Ali International Airport (SDF) | 5 | UPS Airlines | — |
| Fort Lauderdale Hollywood International Airport (FLL) | 4 | Top Air (Turkey) | — |
| Frederick W. Smith International Airport (MEM) | 4 | Four Island Air | — |
| Southwest Florida International Airport (RSW) | 3 | Top Air (Turkey) | — |
| Myrtle Beach International Airport (MYR) | 2 | Mexicana | — |
GET /routes returns each scheduled flight from MHT: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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