31 destinations have scheduled flights from MYR, about 270 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Charlotte Douglas International Airport (CLT) | 34 | American Airlines, Envoy Air Inc. | — |
| LaGuardia Airport (LGA) | 27 | Spirit Airlines, Delta Air Lines | — |
| Ronald Reagan Washington National Airport (DCA) | 23 | American Airlines | — |
| Newark Liberty International Airport (EWR) | 23 | Albatross Airlines, Spirit Airlines | — |
| Hartsfield Jackson Atlanta International Airport (ATL) | 19 | Delta Air Lines | — |
| Baltimore/Washington International Thurgood Marshall Airport (BWI) | 19 | Southwest Airlines Co. | — |
| Philadelphia International Airport (PHL) | 14 | American Airlines | — |
| Dallas Fort Worth International Airport (DFW) | 13 | American Airlines | — |
| Boston Logan International Airport (BOS) | 11 | Spirit Airlines | — |
| Fort Lauderdale Hollywood International Airport (FLL) | 10 | Spirit Airlines, Mexicana | — |
| Bradley International Airport (BDL) | 8 | Mexicana | — |
| Detroit Metropolitan Wayne County Airport (DTW) | 7 | Delta Air Lines | — |
| Nashville International Airport (BNA) | 6 | Southwest Airlines Co. | — |
| Orlando International Airport (MCO) | 6 | Spirit Airlines, Mexicana | — |
| Chicago O'Hare International Airport (ORD) | 6 | Envoy Air Inc. | — |
| Columbia Metropolitan Airport (CAE) | 5 | Stockholmsplanet | — |
| Chicago Midway International Airport (MDW) | 5 | Southwest Airlines Co. | — |
| Rhode Island T. F. Green International Airport (PVD) | 5 | Mexicana | — |
| Tweed New Haven Airport (HVN) | 4 | Xtra Airways | — |
| Tampa International Airport (TPA) | 4 | Mexicana | — |
| Lehigh Valley International Airport (ABE) | 3 | Allegiant Air LLC | — |
| Pickens County Airport (LQK) | 3 | Salaam Express Air Services | — |
| Wilmington Airport (ILG) | 2 | Xtra Airways | — |
| Rickenbacker International Airport (LCK) | 2 | Allegiant Air LLC | — |
| Manchester-Boston Regional Airport (MHT) | 2 | Mexicana | — |
| Louis Armstrong New Orleans International Airport (MSY) | 2 | Mexicana | — |
| Frederick Douglass Greater Rochester International Airport (ROC) | 2 | Mexicana | — |
| Syracuse Hancock International Airport (SYR) | 2 | Allegiant Air LLC | — |
| Albany International Airport (ALB) | 1 | Allegiant Air LLC | — |
| Akron Canton Regional Airport (CAK) | 1 | Allegiant Air LLC | — |
| New York Stewart International Airport (SWF) | 1 | Allegiant Air LLC | — |
GET /routes returns each scheduled flight from MYR: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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