20 destinations have scheduled flights from TUS, about 354 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Phoenix Sky Harbor International Airport (PHX) | 65 | SkyWest Airlines, Envoy Air Inc., American Airlines, Southwest Airlines Co. | — |
| Los Angeles International Airport (LAX) | 58 | Delta Air Lines, SkyWest Airlines, Southwest Airlines Co. | — |
| Denver International Airport (DEN) | 44 | Albatross Airlines, Southwest Airlines Co., Frontier Airlines, Inc. | — |
| Harry Reid International Airport (LAS) | 25 | Southwest Airlines Co., Frontier Airlines, Inc. | — |
| Salt Lake City International Airport (SLC) | 21 | Delta Air Lines | — |
| Dallas Fort Worth International Airport (DFW) | 16 | American Airlines, Frontier Airlines, Inc. | — |
| Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) | 16 | Delta Air Lines, MN Airlines LLC | — |
| Hartsfield Jackson Atlanta International Airport (ATL) | 14 | Delta Air Lines | — |
| Chicago O'Hare International Airport (ORD) | 14 | American Airlines, Albatross Airlines | — |
| George Bush Intercontinental Airport (IAH) | 13 | Mesa Airlines, Inc., Albatross Airlines | — |
| Seattle–Tacoma International Airport (SEA) | 13 | Delta Air Lines, Alaska Airlines | — |
| San Francisco International Airport (SFO) | 12 | Albatross Airlines | — |
| San Diego International Airport (SAN) | 10 | Southwest Airlines Co. | — |
| John Wayne Orange County International Airport (SNA) | 10 | American Airlines, Alaska Airlines | — |
| Chicago Midway International Airport (MDW) | 7 | Southwest Airlines Co. | — |
| Dallas Love Field (DAL) | 4 | Southwest Airlines Co. | — |
| Phoenix Deer Valley Airport (DVT) | 4 | North Coast Aviation | — |
| Frederick W. Smith International Airport (MEM) | 4 | Four Island Air | — |
| Phoenix Goodyear Airport (GYR) | 3 | Vuelos Economicos Centroamericanos | — |
| El Paso International Airport (ELP) | 1 | Four Island Air | — |
GET /routes returns each scheduled flight from TUS: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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