26 destinations have scheduled flights from GSP, about 302 departures a week. Weekly frequencies come from airline schedules and observed departures, not live status.
| Destination | Flights per week | Airlines | Typical duration |
|---|---|---|---|
| Charlotte Douglas International Airport (CLT) | 56 | American Airlines, Envoy Air Inc. | — |
| Hartsfield Jackson Atlanta International Airport (ATL) | 31 | Delta Air Lines | — |
| Chicago O'Hare International Airport (ORD) | 31 | Envoy Air Inc., Albatross Airlines, American Airlines | — |
| LaGuardia Airport (LGA) | 29 | Delta Air Lines, American Airlines | — |
| Ronald Reagan Washington National Airport (DCA) | 21 | American Airlines | — |
| Dallas Fort Worth International Airport (DFW) | 16 | Envoy Air Inc., American Airlines | — |
| Baltimore/Washington International Thurgood Marshall Airport (BWI) | 14 | Southwest Airlines Co. | — |
| Miami International Airport (MIA) | 14 | Envoy Air Inc. | — |
| Nashville International Airport (BNA) | 12 | Southwest Airlines Co. | — |
| Detroit Metropolitan Wayne County Airport (DTW) | 11 | Delta Air Lines | — |
| Newark Liberty International Airport (EWR) | 10 | Albatross Airlines | — |
| Denver International Airport (DEN) | 7 | Albatross Airlines | — |
| Washington Dulles International Airport (IAD) | 7 | Albatross Airlines | — |
| Philadelphia International Airport (PHL) | 7 | American Airlines | — |
| George Bush Intercontinental Airport (IAH) | 6 | Mesa Airlines, Inc. | — |
| Frederick W. Smith International Airport (MEM) | 5 | Four Island Air | — |
| Tweed New Haven Airport (HVN) | 4 | Xtra Airways | — |
| Louisville Muhammad Ali International Airport (SDF) | 4 | UPS Airlines | — |
| Tampa International Airport (TPA) | 4 | Mexicana | — |
| Bradley International Airport (BDL) | 2 | Mexicana | — |
| Liège Airport (LGG) | 2 | First European Airways | — |
| Orlando International Airport (MCO) | 2 | Mexicana | — |
| St. Petersburg Clearwater International Airport (PIE) | 2 | Allegiant Air LLC | — |
| Rhode Island T. F. Green International Airport (PVD) | 2 | Mexicana | — |
| Southwest Florida International Airport (RSW) | 2 | Mexicana | — |
| Orlando Sanford International Airport (SFB) | 1 | Allegiant Air LLC | — |
GET /routes returns each scheduled flight from GSP: airline, flight number, departure and arrival time, duration, days of operation and aircraft type.
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